Clinical Botox

Give Chronic Migraine The Treatment It Deserves!

Meticulous. Mindful. Methodical.

Mindful. Meticulous. Methodical. That is Chronic Migraine treatment with an expert's touch. This foundational treatment is the first FDA approved preventive treatment for Chronic Migraine. BOTOX® is indicated for the prophylaxis of headaches in adult patients with Chronic Migraine (> 15 days per month with headache lasting 4 hours a day or longer).
Preemptive Paradigm 1

BOTOX® for Chronic Migraines in Clinical Trials​

BOTOX® for Chronic Migraine has been studied in clinical trials for nearly a decade. Phase 2 studies established the PREEMPT* Paradigm and led to the pivotal Phase 3 trials upon with BOTOX® FDA approval is based. Treatment is locally administered by trained clinicians via the established PREEMPT program as an in-office procedure. The standardized protocol guides the medication delivery in specific locations. BOTOX® for Chronic Migraine injections take about 15 minutes.

*PREEMPT = Phase 3 REsearch Evaluating Migraine Prophylaxis Therapy.


A diagnosis of Chronic Migraine is headaches 15 days or more per month with headache lasting 4 hours a day or longer.

Only a licensed practitioner can diagnose Chronic Migraine. If you are experiencing headaches 15 days or more per month with headaches lasting 4 hours a day or longer, you may be a candidate. Make an appointment with a practitioner that has been trained to use Botox for Chronic Migraine for a full examination and consultation.
Botox is available to most patients through their insurance. Patients may still have out of pocket costs based on their actual benefit plan and coverage criteria.
In PREEMP trials, BOTOX® patients received at least 2 treatments, 12 weeks apart, to determine effectiveness with the primary end point at 24 weeks. Further re-treatment should be determined per clinician’s discretion. Patients may see some results at Week 4, and then headache day reduction will gradually improve over the 24 weeks.
BOTOX® (onabotulinumtoxinA) is injected into the skin to treat symptoms of severe underarm sweating (severe primary axillary hyperhidrosis) when medicines used on the skin (topical) do not work well enough in people 18 years and older. It is not known whether BOTOX® is safe or effective for severe sweating anywhere other than your armpits. Only a medical professional can diagnose severe underarm sweating that is not being managed effectively with clinical strength antiperspirants. See your CHARM physician with any questions.